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Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important contribution for a healthier society.

The Institute of Translational Stem Cell Research (ITS), headed by Prof. Henrik Semb, focuses on developing stem-cell-based therapies to treat patients with Type 1 Diabetes. ITS is looking for an enthusiastic post-doctoral candidate with a strong background in stem cell biology to generate a human stem cell-based therapy for type 1 diabetes as part of a collaborative H2020 project, the ISLET. The goal of the ISLET project is to pioneer a new advanced cell therapy to treat T1D patients. To accomplish this, ISLET gathers a team of internationally leading experts to establish a GMP-compliant manufacturing program based on improved and standardized protocols for the generation and characterization of future stem-based based therapies.

Postdoc for the Institute of Translational Stem Cell Research (f/m/x) 100734

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Image Neuherberg near Munich
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Your mission

The candidate is expected to establish a highly efficient and robust GMP-compliant manufacturing protocol for a human pluripotent stem-cell-derived beta-cell product with functional properties comparable to human islets. The GMP-compliant protocol will involve translating basic research discoveries in islet fate decisions from Prof. Semb´s lab at DanStem, University of Copenhagen.

Specifically, the candidate will participate in the generation of cell banks using a GMP-grade hESC line and a quality control strategy for the stem cell-derived beta product. Also, the candidate will produce stem-cell-derived beta cells under Good manufacturing practices (GMP) conditions in collaboration with the academic GMP-facility TUMCells. The candidate will work closely with a team of scientists at the Helmholtz Diabetes Center, an interdisciplinary and translational research centre dedicated to diabetes research, with TUMCells and with the partners of the ISLET project.

Your qualifications

  • A PhD in stem cell biology/ developmental biology
  • Experience in human pluripotent stem cell maintenance and differentiation
  • Experience with a 3D culture of pluripotent stem cells
  • Experience with flow cytometry, cell and molecular biological methods, confocal microscopy

Desired qualifications

  • Experience in differentiation towards pancreatic lineage is a plus
  • Experience with animal work is a plus
  • Knowledge of CRISPR/Cas9 gene editing is a plus

What we offer you

continuous education and training
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work-life balance
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flexible working hours & time off in lieu
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30 days annual leave
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on-site health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to 2 years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
Applicant guidance on the Corona pandemic

Interested?
If you have further questions, simply contact Dr. Minodora Brimpari, minodora.brimpari@helmholtz-muenchen.de, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute for Translational Stem Cell Research
Ingolstädter Landstraße 1

85764 Oberschleißheim

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