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Helmholtz Munich is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

The Comprehensive Pneumology Center (CPC, www.cpc-munich.org) at HMGU is a translational research center dedicated to respiratory medicine, which is also a partner site of the German Center for Lung Research (DZL; www.dzl.de), an association of the leading university and non-university institutions dedicated to lung research in Germany.

As part of CoViPa the postdoctoral fellow in the Schiller lab will set up and run several ex-vivo and in-vitro models of human lung, including air-liquid interface culture of primary airway and alveolar epithelial cells, precision cut lung slice cultures, and alveolar organoids. These models will be subjected to virus infections and highly multiplexed biological perturbations (e.g. small molecules targeting pathways, cytokines) coupled to single cell transcriptomic readouts and other omics measurements. 

The CoViPa project: To gain knowledge about the virological and immunological drivers of COVID-19 pathogenesis and the parameters of immune protection, the Helmholtz Association has united experts from 7 Helmholtz Centers in 4 Helmholtz Research Fields (Health, Environment, Information and Aeronautics, Space & Transport) and 3 university partners, to create an internationally visible and interdisciplinary network called COVIPA (https://www.dkfz.de/en/covipa/covipa.html and https://twitter.com/COVIPA1). We are looking for a highly motivated 

Postdoc as part of the CoViPa consortium (f/m/x) 101107

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Your responsibilities

  • Establish and maintain ex vivo models of human lung (organoids, ALI culture and precision cut lung slices)
  • Multiplexed single cell multi-omics method development and testing in human organotypic models
  • Establish and use multiplexed smFISH in the ex vivo models and on patient tissues
  • Integrative bioinformatic analysis of the single cell perturbation omics data from the organotypic models
  • Confocal and light sheet microscopy and image analysis

Our offer

  • Training and supervision in cutting edge technologies (single cell genomics, spatial omics, computational biology, imaging techniques)
  • Team member in Human Cell Atlas consortium working on the Lung

Your qualifications

We are looking for a highly motivated, independent and creative individual with a background in biology or medicine. Prior experience with lung biology and virus-host interactions is an advantage. Furthermore, previous experience with (single cell) genomics or systems biology is expected.

  • PhD degree in biology or related area
  • Previous experience with systems biology and data analysis
  • Previous experience with lung biology
  • Passion for science, innovation and creative and independent work
  • Proficient in written and spoken English

What we offer you

work-life balance
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flexible working hours & working-time models
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continuous education and training
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30 days annual leave
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on-site health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited to , under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

Interested?
If you have further questions, simply contact Dr. Herbert Schiller, herbert.schiller@helmholtz-muenchen.de, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Lung Biology
Max-Lebsche-Platz 31

81377 München

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