Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

Within the Institute of Developmental Genetics our group combines cutting-edge cell and protein engineering methods for developing novel molecular tools to precisely manipulate the genome and transcriptome of cells and organisms. We apply these tools to various disease models ranging from cell lines and patient-derived stem cells to mouse models.

In the past, we used our technologies to treat devastating diseases like Parkinson’s Disease, Duchenne Muscular Dystrophy, or COVID-19 in cellular and animal models. Recently, we developed a synthetic protein to package and transfer RNA into target cell types. With this tool, we were able to express reporter and CRISPR proteins in up to 99% of cells. We now seek to further improve this technology by screening multiple configurations of the transfer protein, by programming target cell types, and by applying the technology to different cellular, ex vivo and in vivo preclinical models.

We are looking for a highly motivated

Postdoc: Molecular engineering of a novel type of genetically encoded RNA delivery vehicle (f/m/x) 101955

Image Full time
Image Neuherberg near Munich
Image Postdocs

Your responsibilities

  • Iterative design, build, test cycle of genetic constructs to express RNA delivery proteins
  • Testing of different cargo RNAs with a focus on CRISPR/Cas enzymes
  • Exploring of novel approaches for cell type-specific delivery (e.g. by transmembrane protein engineering)
  • Analysis of delivery efficiencies in different cellular models and benchmarking against conventional delivery technologies (LNP, AAVs)
  • Writing of manuscripts and drafting of scientific illustrations; Contribution to patent applications and commercialization strategies

Your qualifications

  • PhD in Bioengineering / Molecular Biology / Biotechnology / Biochemistry or related fields
  • Theoretical and practical knowledge of advanced DNA cloning techniques, including synthetic genes, in mammalian cell cultivation, genetic and/or protein engineering
  • Knowledge of Genome Editing technologies (e.g. Cas9, Cas13, Base Editing, Prime Editing, CRISPRa/i) is an advantage
  • Good publication record, preferentially with first author publication
  • Enthusiasm for solving biological problems by applying engineering principals

What we offer you

work-life balance
flexible working hours & working-time models
continuous education and training
30 days annual leave
on-site health management service
Image home office options
Image on-site nursery & holiday care
Image elder care
Image company pension scheme
Image discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited until 31.3.2025, under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

If you have further questions, simply contact Florian Giesert,, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Developmental Genetics
Ingolstädter Landstraße 1

85764 Oberschleißheim

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