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Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important contribution for a healthier society.

Institute for Diabetes and Obesity (IDO) is located at the Helmholtz Zentrum Munich. The institute is focused on the development of personalized preventive and therapeutic strategies for diabetes and obesity. Scientists of many nationalities conduct research at the IDO allowing for a diverse approach to the contemporary field.

The Research Unit Cellular Proteomics and Metabolic Signaling (headed by Dr. Natalie Krahmer) is aiming to establish organelle proteomic workflows to study cellular processes underlying the development of metabolic diseases.

We are looking for a

Postdoc - Cellular Proteomics and Metabolic Signaling (f/m/x) 100532

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Image Neuherberg near Munich
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Your responsibilities

  • Cell biological methods: cell culture, real-time oxygen consumption, Western Blot, Real-time polymerase chain reaction, flow cytometry, confocal imaging, reactive oxygen species detection
  • Analysis of mitochondrial function, mitochondrial bioenergetics, metabolic flux analysis, flow cytometry (e.g., organelle isolation, respiration, production of oxidants, enzymatic activities) 
  • Work with in vivo animal models, especially mouse models of metabolic diseases (e.g., experimental design, housing, diet formulation, administration of substances, blood sampling, liver perfusion)
  • Mitochondria and lipid droplet isolation and proteomics
  • Programming languages: R, Python

Your qualifications

  • PhD in biochemistry, metabolism and molecular biology with background in nutrigenomics, immunometabolism, redox biology
  • Excellent experience in liver cell biology, generation of primary hepatocytes, liver perfusion
  • Experience in lipid droplet and mitochondria isolation and characterization of contact sites, confocal imaging of lipid droplets and mitochondria
  • Mitochondrial characterization by flux analysis, enzymatic assays, Seahorse analysis
  • Excellent skills to work with cell cultures including generation and culturing of primary cells, generation of stably transfected cell lines, siRNA mediated knock down of target genes
  • Great interest and experience to work with mice, FELASA certificates to work with mice are available
  • Excellent experience with in vivo animal models, especially mouse models of metabolic diseases (e.g., experimental design, housing, diet formulation, administration of substances, blood sampling, liver perfusion)
  • Good knowledge in general cell and molecular biological techniques including cell culture, western blot and qPCR, cloning, transfection
  • Good knowledge in English is essential
  • Programming skills

What we offer you

continuous education and training
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work-life balance
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flexible working hours & time off in lieu
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30 days annual leave
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on-site health management service
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Image discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to two years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
Applicant guidance on the Corona pandemic

Interested?
If you have further questions, simply contact Dr. Natalie Krahmer, +49 89 3187-43359, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute for Diabetes and Obesity
Ingolstädter Landstraße 1

85764 Neuherberg

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