Postdoc (f/m/x) in time-resolved single-cell omics and stem cell biology
Full time39 hrs./week
Neuherberg near Munich
We are Helmholtz Munich. We discover breakthrough solutions for better health in a rapidly changing world.
We improve people's quality of life through excellent research. Why not join us and make a difference?
The Helmholtz Pioneer Campus (HPC) founded and funded by Helmholtz Munich stands for the intelligent fusion of biomedical sciences, engineering and digitization. At HPC, top scientific talents from across the globe work together on the development of novel solutions that make a difference in the prevention, diagnosis and treatment of diseases.
We are looking for a postdoc (f/m/x) to join our team to develop new time-resolved single-cell RNA-seq technologies and study the interplay between gene oscillations and cellular decision making in stress and during differentiation.
At the Battich lab we are an interdisciplinary team that loves to develop cutting-edge quantitative methods for single-cell genomics and combine them with cellular phenotyping using high-content confocal microscopy. We design data-driven approaches and build quantitative predictive models and use state-of-the-art machine-learning to gain insights into the cellular processes we study.
Your tasks
- Design and characterize new single-cell sequencing approaches to study gene expression dynamics and oscillations, based on metabolic labelling of RNA.
- Characterize the genome wide dynamics in expression in different differentiation systems such as models of embryo segmentation and/or neural differentiation.
- Work in a team to build quantitative models of gene expression dynamics based on interpretable AI.
- Elucidate mechanisms of how transcriptional dynamics propagate through the genome via gene regulatory networks.
- Analyse and integrate diverse datasets (e.g., single-cell genomics, proteomics and high-throughput fluorescent microscopy).
- Use CRISPR-Cas9 perturbation of chromatin regulators to investigate their effects on single-cell transcriptional dynamics.
Your profile
- PhD in Systems Biology, Genetics, Molecular & Cell Biology or a related quantitative biology discipline.
- Good publication record with evidence of independence (at least one first-author publication in an international journal).
- Interest and experience combining computational and experimental work, including demonstrated competency in scientific programming.
- Experience performing next-generation sequencing experiments, and/or CRISPR-Cas9 technology.
- Fluent in written and spoken English.
Desirable qualifications
- Experience with experimental work using stem cells or organoid model systems.
Benefits
- Career Development: Postdoc program, scientific training & career center with tailored offers
- Recreation: 30 days annual leave, flexi days, plus public holidays
- International Staff Service: Support with the relocation and integration process in Germany
- Health Promotion: Sports, company doctor, mental health initiatives
Since 2005, we hold the TOTAL E-QUALITY award for exemplary action in the sense of an equal-opportunity organizational culture.
Helmholtz Munich is actively committed to diversity and inclusion in practice and is sustainably committed to equality.
The Diversity Charter has set itself the goal of promoting diversity in the world of work. By signing the charter, we commit ourselves to create an appreciative working environment for all employees.
If you fulfil all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). The position has an (initial) fixed term of 2 years but may be extended under certain circumstances.
We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.
Interested in applying?
- CV
- Cover letter
- Degrees/Diplomas/Certificates
- Contact details for at least two referees
