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Postdoc (f/m/x) - Repetitive elements in the control of cell identity

102325

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39 hrs./week
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We are Helmholtz Munich. In a rapidly changing world, we discover breakthrough solutions for better health.

Our research is focused within the areas of metabolic health/diabetes, environmental health, molecular targets and therapies, cell programming and repair, bioengineering, and computational health. We particularly excel in the fields of basic research, bioengineering, artificial intelligence, and technological development.

Through this research, we build the foundations for medical innovation. Together with our partners, we seek to accelerate the transfer of our research, so that laboratory ideas can reach society and improve people’s quality of life at the fastest rate possible.

This is what drives us. Why not join us and make a difference?


The Institute of Epigenetics and Stem Cells (IES) is looking for a highly motivated Postdoc interested in investigating repetitive elements in the control of cell identity.

Fertilisation of an oocyte by the sperm results in the generation of a totipotent zygote, which has the inherent ability to form a new organism. This is followed by epigenetic reprogramming of both parental genomes, which includes heterochromatin formation and activation of repetitive elements. The functional significance of this is largely not understood, yet, recent evidence indicates that this remodelling underlies cellular plasticity. Importantly, repetitive elements are often found misregulated in degenerative diseases, during ageing or in cancer. Thus, understanding their biological relevance is of fundamental importance.

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Prof. Matthias Tschöp (Dr. Med., Dr. hc.), CEO of Helmholtz Munich:

"We believe that excellent research requires a range of different perspectives. Diverse teams reach better solutions and are more innovative in their research topics.

Establishing our Diversity Management Strategy demonstrates our commitment to ensuring an appreciative company culture based on mutual respect. We are also implementing diversity-sensitive processes throughout our whole organization."

Your tasks

The successful candidate will study how repetitive elements regulate basic chromatin processes including transcription and replication in stem cells.

The approaches used involve manipulation of large datasets, screening design, NGS, high-throughput gene editing and clonal analysis of gene expression to understand genome reprogramming and transcriptional regulation during development.

Working language is English. We offer a well-equipped, international and scientifically stimulating environment for postdoctoral training.

Your profile

  • Ph.D in molecular cell biology with a solid training in molecular life sciences and chemistry with at least 2 years of experience after obtaining doctoral degree.
  • Previous hands-on experience in molecular biology including scRNA-seq and scATAC-seq library preparation, DNA and RNA modifications and Crispr-Cas9 screening design
  • Previous work on mouse and human tissues and cell culture as well as FACS
  • Full command of English, written and spoken
  • Track-record proven by 2 first author publications
  • Experience in implementing novel genome-wide protocols and screening for the identification of transcription factors will be a plus

Benefits

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Since 2005, we hold the TOTAL E-QUALITY award for exemplary action in the sense of an equal-opportunity organizational culture.

Helmholtz Munich is actively committed to diversity and inclusion in practice and is sustainably committed to equality.

The Diversity Charter has set itself the goal of promoting diversity in the world of work. By signing the charter, we commit ourselves to create an appreciative working environment for all employees.

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If you fulfil all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). This position is for a fixed term of 2 years.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

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Interested in applying?

If you have any questions, feel free to contact Fr. Prof. Dr. Maria Torres-Padilla, 089 3187-3317, who will be happy to help.

Your application should include

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