Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

The UNLEASH Synergy project, which is jointly funded by the European Research Council (ERC) and UK Research and Innovation (UKRI), is a 6-year international collaborative programme that will study mechanisms controlling alternative pre-mRNA splicing in human cells and how it can be modulated using small molecules. The UNLEASH team are taking an interdisciplinary approach to understand splice site selection, with chemical, molecular, cellular and structural biology, combined with proteomics, computational analysis and deep learning. Our aim is to identify new, drug-like small molecules that can control alternative splicing decisions and characterise their detailed mechanisms of action. Ultimately, this will help us to facilitate the development of new therapeutics, targeting alternative splicing events for the treatment of human diseases of current unmet need.

The UNLEASH team combines the complementary expertise of the research groups of Profs. David Gray and Angus Lamond (University of Dundee, UK), Michael Sattler (Helmholtz Munich, Germany) and Juan Valcárcel (Center for Genomic Regulation, Barcelona, Spain). Opportunities will be available also for joint appointments and mobility will be encouraged for team members to spend time working across the respective sites. The UNLEASH project provides a unique opportunity to contribute to a truly interdisciplinary European collaborative project with the potential to deliver a major advance in biomedical research. Additionally, you will have access to state-of-the-art wet-lab facilities and outstanding cryo-EM, NMR and computational infrastructure at Helmholtz Munich.

We are offering two positions as

Postdoc - Mechanisms to Control Alternative Splicing (f/m/x) 102086

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Image Garching
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Your responsibilities

  • Integrative structural biology of protein-RNA complexes and small molecule interactions, focusing on cryo-EM single-particle analysis, integrated with X-ray crystallography and NMR spectroscopy
  • Protein/RNA biochemistry, reconstitution and purification of protein-RNA complexes from eukaryotic and bacterial cell culture
  • Biochemical and biophysical analysis of protein-RNA interactions, splicing assays activity in cells and extracts

Your qualifications

  • Doctoral degree in natural sciences (biochemistry, chemistry, bio/physics, biology, or related discipline)
  • Excellent track record, research achievements and publications
  • Expertise in at least one of these areas:
    • cryo-EM SPA and integrative structural biology, biochemical and biophysical methods, experience with XL-MS, (experience with crystallography and/or NMR is a plus)
    • cell culture (bacterial and eukaryotic) for protein expression and purification of protein complexes, and biochemical/functional assays
  • Knowledge and interest in understanding mechanisms of splicing regulation
  • Strong motivation, scientific curiosity, and commitment to scientific excellence
  • Excellent writing and communication skills and motivation to publish
  • Team player and enthusiasm to work in an international multi-disciplinary and collaborative environment

What we offer you

work-life balance
flexible working hours & working-time models
continuous education and training
30 days annual leave
on-site health management service
Image excellent research infrastructure
Image on-site nursery & holiday care
Image elder care
Image company pension scheme
Image discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited to two years, under certain circumstances an extension can be arranged.

Interested candidates should send their CV, including the names of 3 referees who can be contacted for references, and should also include a 1-page statement indicating their motivation for joining the UNLEASH project.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

If you have further questions, simply contact Karen Biniossek, 089 3187-2508, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Bavarian NMR Center

Institute of Structural Biology
Ernst-Otto-Fischer-Straße 2

85748 Garching

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