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Postdoc - Adaptive immunity biomarkers for the diagnosis of chronic obstructive pulmonary disease (f/m/x)

102288

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We are Helmholtz Munich. In a rapidly changing world, we discover breakthrough solutions for better health.

Our research is focused within the areas of metabolic health/diabetes, environmental health, molecular targets and therapies, cell programming and repair, bioengineering, and computational health. We particularly excel in the fields of basic research, bioengineering, artificial intelligence, and technological development.

Through this research, we build the foundations for medical innovation. Together with our partners, we seek to accelerate the transfer of our research, so that laboratory ideas can reach society and improve people’s quality of life at the fastest rate possible.

This is what drives us. Why not join us and make a difference?


Are you passionate about science, full of ideas and innovative potential that drive change, and enjoy working in an international, fast-paced environment? Are you motivated by the societal impact of research and seek an opportunity to play an instrumental part in understanding the underlying molecular pathogenic mechanisms of disease? Then the Institute of Lung Health and Immunity (LHI) at Helmholtz Munich, Germany is the ideal environment for you!

Chronic obstructive pulmonary disease (COPD) is a persistent respiratory disease marked by irreversible small airway obstruction, impacting over 400 million individuals globally. T cells play a pivotal role in COPD pathophysiology, correlating with lung tissue damage. Despite their significance, reliable T cell-derived biomarkers for early COPD diagnosis remain elusive. To this end, the comprehensive phenotyping and the determination of T cell anatomical localization show promise in identifying clinically relevant subsets and understanding the functional dysregulation via major lung injury mechanisms. Additionally, the characterization of T cell repertoires throughout COPD progression could unveil evidence of potential immune tolerance breakdown in the lung.

To explore the T cell diversity and functions in COPD, the Kapellos group is seeking a postdoctoral scientist (f/m/x). The successful candidate will work on: Adaptive immune cell-derived biomarkers for the early diagnosis of chronic obstructive pulmonary disease.

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Prof. Matthias Tschöp (Dr. Med., Dr. hc.), CEO of Helmholtz Munich:

"We believe that excellent research requires a range of different perspectives. Diverse teams reach better solutions and are more innovative in their research topics.

Establishing our Diversity Management Strategy demonstrates our commitment to ensuring an appreciative company culture based on mutual respect. We are also implementing diversity-sensitive processes throughout our whole organization."

Your tasks

  • analyze scRNA-seq, CITE-seq and VDJ sequencing data from lung samples
  • set up and run a pipeline for imaging data analysis
  • contribute to the establishment of new bioinformatics pipelines for the group
  • participate in collaborative bioinformatics projects
  • present work in national and international scientific meetings
  • write reports and contribute to the groups scientific success

Your profile

  • PhD degree in bioinformatics, data science or similar
  • Proficiency in written and spoken English
  • Profound background in programming (R/Python)

Desired qualifications:

  • Previous experience with single-cell genomics data analysis
  • Exposure to genomics lab protocols (e.g. library preparation, sequencing)
  • Enthusiasm to work in an interdisciplinary group consisting of basic scientists, clinicians and bioinformaticians
  • Highly organized, good time management skills and ability to manage multiple priorities
  • Proactive and forward-thinking approach
  • Open to continuous learning and ability to work independently

Benefits

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Since 2005, we hold the TOTAL E-QUALITY award for exemplary action in the sense of an equal-opportunity organizational culture.

Helmholtz Munich is actively committed to diversity and inclusion in practice and is sustainably committed to equality.

The Diversity Charter has set itself the goal of promoting diversity in the world of work. By signing the charter, we commit ourselves to create an appreciative working environment for all employees.

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If you fulfil all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). The position has an (initial) fixed term of 26 months but may be extended under certain circumstances.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

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Interested in applying?

If you have any questions, feel free to contact Dr. Theodoros Kapellos, theodoros.kapellos@helmholtz-munich.de, who will be happy to help.

Your application should include

    We are Helmholtz Munich.

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