Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important contribution for a healthier society.

We are looking for a highly motivated postdoctoral fellow to join our international research team at the Institute for Diabetes and Obesity (IDO) of the newly established Helmholtz Diabetes Center (HDC) in Munich. The Helmholtz Center Munich is a member of one of the leading research associations in Europe – the Helmholtz Association of German Research Centers. Our laboratory (Research Unit in Functional Genomics of Mitochondria, headed by Dr. Fabiana Perocchi) is interested in characterizing mitochondrial signal transduction cascades that occur in response to physiological and pathophysiological stimuli (e.g. exercise and diet). We develop experimental and computational strategies to predict, test, and reverse the effects of genetic and chemical perturbations on mitochondrial metabolism. To this goal, we combine genomics, proteomics, and metabolomics approaches with traditional genetic, biochemical, and physiological techniques applied to mouse models, human cell lines and patient samples. The aim of the postdoc research project is to characterize the role of newly identified calcium-regulated proteins in mitochondrial signaling and metabolism.

Postdoc - regulation of the mitochondrial calcium uniporter complex (f/m/x) 100561

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Your responsibilities

  • Study of the regulation of the mitochondrial calcium uniporter complex
  • Define the role of new interactors on MCU and bioenergetics
  • Characterize the MCU complex stoichiometry in mouse tissues
  • Train PhD students in calcium imaging
  • Writing of manuscripts

Your qualifications

  • Strong experimental skills in calcium imaging (mandatory)
  • Strong experimental skills in live imaging and immunofluorescence (mandatory)
  • Strong experimental skills in generating genetically modified cell lines through viral vectors (lentivirus, retrovirus, adenovirus; CRISPR-Cas9)
  • Strong experimental skills in mouse phenotyping, animal handling, and surgical procedure (mandatory)

What we offer you

continuous education and training
work-life balance
flexible working hours & time off in lieu
30 days annual leave
on-site health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to 1, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age until . Qualified applicants with physical disabilities will be given preference.
Applicant guidance on the Corona pandemic

If you have further questions, simply contact Fabiana Perocchi, +49 89 3187-43056, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute for Diabetes and Obesity
Ingolstädter Landstraße 1

85764 Neuherberg near Munich

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