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Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

The research group “human endogenous retroviruses” investigates the influence of HERV sequences on neural and brain development. HERVs are remnants of ancient germ line infections that have been genetically fixed and vertically transmitted since millions of years. Activation of HERV sequences can contribute to diseases by expression of pathogenic viral proteins or influencing the expression of cellular genes. Several recent studies, including our own, indicate that the tight regulation of HERVs is essential for a healthy brain and that dysregulation may be associated with neurodegenerative diseases. Therefore, we want to understand the functional role and regulation of HERV sequences during brain development.

The Vincendeau lab is searching for a highly motivated Postdoc (f/m/x) starting November 1st, 2022.

Postdoc - Human endogenous Retroviruses in brain development (f/m/x) 101629

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Image Neuherberg near Munich
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Your responsibilities

  • Investigating the functional role of HERVs on neural development using CRISPRi/a approaches in human stem cell and brain organoid models
  • Studying the molecular mechanisms how HERVs are regulated during brain development
  • Establishing workflows to elucidate molecular and functional changes on neural development
  • Planning and execution of research projects at the interface of virology, molecular biology and developmental biology
  • Independent planning, execution and analysis of experiments
  • Analysis and interpretation of research data
  • Publication and presentation of research results
  • Professional supervision of (PhD) students

Your qualifications

  • PhD or equivalent level of professional qualification in molecular biology, virology, developmental biology or a related discipline
  • Theoretical and practical expertise in molecular and cell biology, virology and developmental research
  • Strong expertise in working with human stem cells and brain organoid models using neural differentiation protocols is a must
  • Hands-on experience in utilizing CRISPR technologies
  • Good knowledge in confocal imaging is a plus
  • Enthusiasm to work in an international and interdisciplinary research team
  • High motivation, flexibility as well as innovative and creative thinking are a must
  • Excellent written and verbal communication English skills
  • A strong academic record documented by publications in high-ranking journals

What we offer you

work-life balance
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flexible working hours & working-time models
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continuous education and training
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30 days annual leave
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on-site health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited to one year, under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

Interested?
If you have further questions, simply contact Michelle Vincendeau, +49 89 3187 3644, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Virology
Ingolstädter Landstraße 1

85764 Oberschleißheim

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