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Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important contribution for a healthier society.

The Institute of Translational Genomics (ITG) translates insights from genomics and multi-omics into mechanisms of complex disease development and progression. We are seeking a Postdoctoral Fellow to work on multimodal data integration for modelling type-2 diabetes (T2D) outcomes.

The successful candidate will join a dynamic and international team of analysts and researchers in a consortial collaboration funded in the EU Horizon2020 framework, which brings together private and research actors to achieve a paradigm shift in T2D healthcare. The successful applicant will work on rich in-house datasets comprising T2D-relevant clinical outcomes, as well as genetic, proteomic and metabolomic data. The UK Biobank will be used as a replication cohort.

At ITG, we have a strong track record in helping you progress your scientific career. There will be opportunities to supervise PhD students, and you will be able to communicate your results widely to the community, through high-impact publications and presentations at international conferences.

Postdoc in Translational Genomics (f/m/x) 100862

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Image Neuherberg near Munich
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Your responsibilities

  • Identification and validation of robust associations between dynamic molecular and imaging traits and clinical outcomes
  • Identification and validation of robust molecular and imaging quantitative trait loci (QTLs)
  • Identification of effector genes for unresolved GWAS signals
  • Identification of novel drug targets and drug repositioning opportunities
  • Identification and validation of robust changes in imaging traits and correlation to clinical outcomes
  • Assessment of the prediction performance of existing polygenic risk scores to predict type 2 diabetes onset and the development of complications (neuropathy and atherosclerosis)
  • Production and validation of stratified PRS based on the quantitative traits measured to provide better stratification for patient groups likely to progress to disease and to complications
  • Development and validation on integrated prediction score combining metabolomics, proteomics, genetics and imaging measurements

Your qualifications

  • A PhD in Human Genetics or a related field
  • Practical experience of data analysis and visualisation with R or Python
  • Familiarity with *NIX environments and the bash scripting language
  • Knowledge of basic bioinformatics resources (Ensembl, the GWAS Catalog, genome annotation and expression databases etc.)
  • Familiarity with common statistical genetics tools (e.g. plink, bcftools)
  • Spoken and written fluency in English

What we offer you

continuous education and training
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work-life balance
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flexible working hours & time off in lieu
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30 days annual leave
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on-site health management service
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Image company pension scheme
Image discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to 2-year contract with possibility of extension up to 4 years.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
Applicant guidance on the Corona pandemic

Interested?
If you have further questions, simply contact Marion Timm, marion.timm@helmholtz-muenchen.de, +49-89-3187-49614, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Translational Genomics
Ingolstädter Landstraße 1

85764 Oberschleißheim

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