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Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

News on the Corona pandemic
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We continue to recruit and are looking exactly for you. To this end, we have adapted our recruitment process to ensure the greatest possible health protection for both our applicants and our employees. After successfully reviewing your application documents, we will invite you to a friendly video call or telephone interview, no special devices needed. Here we simulate a face-to-face interview situation in order to get to know you better. Fight with us against the spread of environmentally related diseases and apply now.

With us you will support renowned researchers in a vibrant international environment. Their task is to improve people’s quality of life with excellent research results.

Chronic lung diseases are the research focus of the Institute of Lung Biology and Disease (ILBD) and the Comprehensive Pneumology Center (CPC). Targeting the role of originating factors and key pathways of disease development, all work is determined to contribute to strategies of disease prevention and the establishment of novel diagnostic and therapeutic approaches in the area of chronic lung disease.

We are offering a

PhD position - Proteasome Function in Lung Disease (f/m/d) 100241

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Your mission

  • The lung epithelium is the first line of defense for airborne environmental challenges such as noxious chemicals, particles and infectious viruses such as SARS-CoV2. Lung epithelial cells respond to cellular stress or respiratory infections by secreting interferons that initiate innate and adaptive immune responses. Release of type I interferons by the lung epithelium rapidly recruits and activates monocytes/macrophages as well as natural killer cells which subsequently activate T cell to clear virus infected cells.
  • In this PhD project, we will systematically dissect the interferon-induced immune response of lung bronchial and alveolar epithelial cells as induced by virus infections, LPS and cellular stress using in vitro human co-culture systems with immune cells as well as in vivo animal models and advanced in intravital microscopy of the lung.
  • We will further analyze regulation of interferon-mediated innate and adaptive immune responses by applying KO mouse models as well as pharmacological inhibitors.

Your qualifications

  • Candidates should have a solid background in molecular biology and immunology as well as experience in cell biology, microscopy and preferentially mouse work
  • Applicants should have demonstrated outstanding performance through their undergraduate studies
  • Besides creativity, a strong ability for problem solving through analytical thinking combined with an enthusiasm for scientific research is highly desirable
  • Additionally, we expect good communication skills, fluent English and the ability for teamwork
  • the successful applicant will join an enthusiastic and collaborative group where a multidisciplinary approach is pursued

What we offer you

goal-orientated professional development Image
compatibility of private life & work Image
flexible working hours, flexitime, without core times
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30 days vacation per year Image
in-house health management Image
Image a nursery directly at the campus
Image Elder Care & further consultation offers
Image company pension scheme
Image discounted job ticket (MVV and DB)
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and research institutes it offers an intellectually stimulating environment.

This position also provides the opportunity for you to build specialist knowledge and collect significant professional experience, both of which will help advance your scientific career.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled. The position is (initially) limited to three years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.

Curious?
If you have further questions, simply contact
Prof. Silke Meiners, silke.meiners@helmholtz-muenchen.de, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Lung Biology and Disease
Comprehensive Pneumology Center (CPC)
Max-Lebsche-Platz 31

81377 Munich

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