Helmholtz Munich is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

The Helmholtz Pioneer Campus (HPC) founded and funded by the Helmholtz Center Munich stands for the intelligent fusion of biomedical sciences, engineering and digitization. At HPC, top scientific talents from across the globe work together on the development of novel solutions that make a difference in the prevention, diagnosis and treatment of diseases.

The 3D Genome and Molecular Neuroscience group headed by Dr Boyan Bonev studies the epigenetic mechanisms of gene regulation during development. The goal of this project is to identify novel factors controlling 3D genome organization during neural development.

We are looking for a highly motivated

PhD candidate in molecular mechanisms of 3D genome rewiring (f/m/x) 101628

Image Full time
Image Martinsried
Image PhD

Your mission

  • Employ CRISPR genome engineering to develop stable transgenic mouse stem cell lines
  • Develop high-throughput reporter assay to measure 3D chromatin proximity
  • Determine the influence of genomic distance to transcriptional activation
  • Independently plan, conduct and describe scientific experiments in the area of epigenetics
  • Research scientific literature and prepare manuscripts for publication in peer-reviewed journals

Your qualifications

  • M. Sc. in life sciences (completed or expecting to complete) with focus on genomics, development or epigenetics
  • Strong motivation for pursuing an ambitious research agenda
  • Creativity, excellent analytical, technical and problem solving skills
  • Expertise in mammalian cell culture and epigenetics
  • Experience with NGS technologies
  • Experience with high-throughput CRISPR screening - desired
  • Computational experience with NGS (R, shell scripting, python) - desired

What we offer you

scientific training at HELENA Graduate School Image
work-life balance Image
flexible working hours
30 days annual leave
on-site health management service
Image career consultation
Image home office options
Image on-site nursery
Image company pension scheme
Image discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

This position also provides the opportunity for you to build specialist knowledge and collect significant professional experience, both of which will help advance your scientific career.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled. The position is (initially) limited to three years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

Curious? If you have further questions, simply contact Dr. Boyan Bonev, +49 89 2180-71902, who will be happy to be of assistance.

Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Helmholtz Pioneer Campus
Ingolstädter Landstraße 1

85764 Neuherberg near Munich

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