Helmholtz Munich is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.
The Helmholtz Pioneer Campus (HPC) founded and funded by Helmholtz Munich stands for the intelligent fusion of biomedical sciences, engineering and digitization. At HPC, top scientific talents from across the globe work together on the development of novel solutions that make a difference in the prevention, diagnosis and treatment of diseases.
The Battich Lab studies the interplay between nuclear organization, the dynamics of chromatin architecture and the control of gene expression during differentiation of human embryonic stem cells. This position is funded by our ERC Starting Grant.
To study the interplay between the dynamics of chromatin architecture, nuclear organization, and the control of gene expression during differentiation of human embryonic stem cells, we are looking for a highly motivated
Your responsibilities
- To design new single-cell sequencing approaches to study nuclear sub-compartmentalization of chromatin
- To characterize changes in chromatin structure and nuclear membrane-less organelles during differentiation of human embryonic stem cells
- Perform CRISPRi and CRISPRa screens using state-of-the-art single-cell -omics and/or microscopy tools to investigate the functional link between compartments, chromatin conformation, and transcription
- Infer developmental trajectories of single cells during mouse and human embryonic stem cell differentiation, during the establishment of embryonic organoids systems
- Participate in the analysis and integration of diverse datasets (e.g., single-cell genomics, proteomics and high-throughput fluorescent microscopy)
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Your qualifications
- PhD in Systems Biology, Genetics, Molecular & Cell Biology or a related quantitative biology discipline
- Good publication record with evidence of independence (at least one first-author publication in an excellent international journal)
- Interest and experience combing computational and experimental work, including demonstrated competency in scientific programming
- Experience performing next-generation sequencing experiments and/or state-of-the-art fluorescent microscopy
- Fluent in written and spoken English
Desirable qualifications
- Experience with experimental work using embryonic stem cells and/or knowledge of epigenetics
- Experience with CRISPR-Cas9 technology
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work-life balance |
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flexible working hours & working-time models |
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continuous education and training |
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30 days annual leave
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on-site health management service
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home office options |
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on-site nursery & holiday care |
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elder care |
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company pension scheme |
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discounted public transport ticket |
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.
Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited to two years, under certain circumstances an extension can be arranged.
To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.
Curious? If you have further questions, simply contact Nicolas Battich, nicolas.battich@helmholtz-muenchen.de, who will be happy to be of assistance.
