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Postdoc - Systems analysis of perinatal human lung development (f/m/x)

102291

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39 hrs/week
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We are Helmholtz Munich. In a rapidly changing world, we discover breakthrough solutions for better health.

Our research is focused within the areas of metabolic health/diabetes, environmental health, molecular targets and therapies, cell programming and repair, bioengineering, and computational health. We particularly excel in the fields of basic research, bioengineering, artificial intelligence, and technological development.

Through this research, we build the foundations for medical innovation. Together with our partners, we seek to accelerate the transfer of our research, so that laboratory ideas can reach society and improve people’s quality of life at the fastest rate possible.

This is what drives us. Why not join us and make a difference?


We are looking for a highly motivated postdoctoral scientist (f/m/x) to join the Schiller lab (https://twitter.com/SchillerLab; Pubmed: Schiller HB) at the Institute of Lung Health and Immunity / Comprehensive Pneumology Center.

Background

At birth, the newborn's immune system is suddenly exposed to microorganisms, food and numerous other environmental influences. How do the infants‘ immune cells prepare for this moment during pregnancy and birth? How do external influences and genetic factors interact to shape the immune system during the first weeks of life? And what are the consequences of disruptive events, such as premature birth or neonatal infections?

In the context of the transregional Collaborative Research Center, funded by the German Research Foundation (DFG) PILOT (TRR 359 “Perinatal Development of Immune Cell Topology”), we are aiming to analyze immune cell trajectories defining early lung development in newborn infants (https://www.perinatal-immunity.de/en/project/a08).

In addition, in the context of a CZI funded consortium we are currently using spatial proteomics to map tissue niches in postnatal development of the human lung.

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Prof. Matthias Tschöp (Dr. Med., Dr. hc.), CEO of Helmholtz Munich:

"We believe that excellent research requires a range of different perspectives. Diverse teams reach better solutions and are more innovative in their research topics.

Establishing our Diversity Management Strategy demonstrates our commitment to ensuring an appreciative company culture based on mutual respect. We are also implementing diversity-sensitive processes throughout our whole organization."

Your tasks

  • Longitudinal single cell transcriptomics of cells from neonate respiratory fluids and blood
  • Analysis and biological interpretation of results
  • Close collaboration with computational biologists on analysis of multimodal data for integration of single cell analysis from respiratory fluids with in situ experiments in FFPE tissue specimens (multiplexed IF and spatial omics)
  • Hypothesis generation and functional interrogations in organoid models
  • Daily supervision of graduate and undergraduate students and lab technicians
  • Project team management and scientific paper writing

Your profile

  • PhD degree in the life sciences or a related field
  • Proficiency in written and spoken English, excellent interpersonal and analytical skills
  • Expertise in lung development and/or immunology is beneficial
  • Expertise in (single cell) omics techniques, systems biology and basic bioinformatic data analysis (R/Python) is beneficial
  • Prior experience with complex ex vivo models (e.g. organoids) is beneficial

Benefits

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Since 2005, we hold the TOTAL E-QUALITY award for exemplary action in the sense of an equal-opportunity organizational culture.

Helmholtz Munich is actively committed to diversity and inclusion in practice and is sustainably committed to equality.

The Diversity Charter has set itself the goal of promoting diversity in the world of work. By signing the charter, we commit ourselves to create an appreciative working environment for all employees.

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If you fulfil all the requirements, you may be eligible for a salary grade of up to E 13. Social benefits are based on the Collective Wage Agreement for Public-Sector Employees (TVöD). The position has an (initial) fixed term of 2 years but may be extended under certain circumstances.

We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we will require further documents from you regarding the comparability of your degree. Please request the Statement of Comparability for Foreign Higher Education Qualifications as early as possible.

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Interested in applying?

If you have any questions, feel free to contact Prof. Dr. Herbert Schiller, herbert.schiller@helmholtz-munich.de, who will be happy to help.

We are Helmholtz Munich.

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Why join us?

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