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Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

Within the Institute of Developmental Genetics we combine cutting-edge cell and protein engineering methods for developing novel molecular tools to precisely manipulate the genome and transcriptome of cells and organisms. We apply these tools to various disease models ranging from cell lines and patient-derived stem cells to mouse models.

In the past, we used our technologies to treat devastating diseases like Parkinson’s Disease, Duchenne Muscular Dystrophy, or COVID-19 in cellular and animal models. Recently, we developed a synthetic protein to package and transfer RNA into target cell types. With this tool, we were able to express reporter and CRISPR proteins in up to 99% of cells. We now seek to further improve this technology by screening multiple configurations of the transfer protein, by programming target cell types, and by applying the technology to different cellular, ex vivo, and in vivo preclinical models.

We are looking for a highly motivated

Postdoc: Application of a novel type of delivery vehicle to transfer RNA into stem cells and primary mouse tissue (f/m/x) 101956

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Image Neuherberg near Munich
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Your responsibilities

  • Transfer and analysis of delivery efficiency of different RNA cargos into cellular models including hiPSCs and their derivatives to induce gene activation, differentiation processes, genome editing, etc.
  • Characterization cell-type specificity, immunological, morphological, and molecular response to cargo delivery in differentiated stem cells and isolated primary mouse tissue and benchmarking against conventional delivery technologies (LNP, AAVs)
  • Supporting in vivo proof-of-concept studies
  • Writing of manuscripts and drafting of scientific illustrations; Contribution to patent applications and commercialization strategies

Your qualifications

  • PhD in Biology / Life Sciences / Biotechnology / Biochemistry or related fields
  • Experience in maintaining and differentiating stem cells into different cell types and/or isolation and cultivation of different primary mouse tissue
  • Skills in transcriptomic profiling of cell types and states (bulk RNA-Seq and/or Single-cell Sequencing) as well as knowledge of Genome Editing technologies (e.g., Cas9, Cas13, Base Editing, Prime Editing, CRISPRa/i) is an advantage
  • Experience in the work with mice desired
  • Passion for innovating at the interface of research and clinical translation and enthusiasm for applying molecular tools to solve biomedical needs

What we offer you

work-life balance
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flexible working hours & working-time models
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continuous education and training
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30 days annual leave
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on-site health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Provided that the prerequisites are fulfilled, a salary level up to E 13 is possible. Social benefits are based on the collective agreement for the federal public service (TVöD). The position is (initially) limited until 31.03.2025, under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

Interested?
If you have further questions, simply contact Florian Giesert, florian.giesert@helmholtz-muenchen.de, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Developmental Genetics
Ingolstädter Landstraße 1

85764 Oberschleißheim

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