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Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

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We continue to recruit and are looking exactly for you. To this end, we have adapted our recruitment process to ensure the greatest possible health protection for both our applicants and our employees. After successfully reviewing your application documents, we will invite you to a friendly video call or telephone interview, no special devices needed. Here we simulate a face-to-face interview situation in order to get to know you better. Fight with us against the spread of environmentally related diseases and apply now.

For many patients with chronic lung disease lung transplantation is the only therapeutic option available. However, long-term survival is severely compromised by chronic rejection – chronic lung allograft dysfunction (CLAD). Bronchiolitis obliterans syndrome (BOS) is the main manifestation of CLAD, leading to poor long-term survival and affecting 50% of patients within 5 years.

The pathogenesis of BOS has been defined by severe mononuclear infiltration of the airways, associated with a fibrogenic deposition in the airways that contributes to a decline in lung function. In current diagnostic practice, the recognition of early allograft dysfunction is limited due to the absence of symptoms and specific measures or biomarkers. Crucially, we have discovered a significant increase of CatB activity in BALF and lung tissue from BOS patients, as well as in our murine model of BOS. Moreover, CatB activity was associated with an increased biosynthesis of collagen, and negatively affected lung function.

The specific aim of this study is to develop a predictive model, which will identify lung transplant recipients at risk of developing BOS within the first year after surgery. By improving the early prediction of BOS, the biomarker signatures are expected to improve patient outcomes and enable effective, personalized medical interventions.

We, the Institute of Lung Biology, are looking for a highly motivated

Postdoc - "Biomarkers and targets in bronchiolotis obliterans syndrome (BOS) after lung transplantation" (f/m/x) 100535

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Your responsibilities

  • Analysis of patient samples (Blood, BALF, tissue biopsies)
  • Planning, and performing in vivo experiments
  • Strong background in molecular and cellular biology; FRET-based assays, ELISA and Western blot assays to determine protein expression
  • Histopathology analysis and imaging
  • Project management (Data analysis, quality assurance and monitoring, interaction with clinical partners and statisticians, writing of reports and publications)

Your qualifications

  • PhD degree in biology or related area and previous experience with molecular biological techniques
  • Passion for science, innovation and creative and independent work
  • Excellent communication and teamwork skills
  • Excellent written and spoken English
  • Desired qualifications
  • Previous experience with lung or transplantation advantageous but not crucial

What we offer you

continuous education & training
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work life balance
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flexible working hours & time off in lieu
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30 days annual leave
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onsite health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to 3 years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.

Interested?
If you have further questions, simply contact Dr. Tom Conlon, thomas.conlon@helmholtz-muenchen.de, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Lung Biology and Disease
Ingolstädter Landstraße 1

85764 Neuherberg

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