Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

Many environmentally triggered lung diseases are still considered incurable. The Institute of Lung Health and Immunity explores the immunological mechanisms underlying chronic lung diseases such as COPD, lung fibrosis, asthma, lung cancer and the complications following lung transplantation. Innate immune memory is a type of immune response that occurs in almost all higher organisms. This type of defense response represents a long-term modulation of the immune system in response to a pathogen, or other stressors, enabling a more effective response to a future attack.

We aim to understand the molecular pathways involved in human trained immunity. Special focus lies on the signaling function of reactive oxygen and nitrogen species in innate immunity and how these molecules regulate metabolic and epigenetic reprogramming during the training phase.

PhD candidate – Redox-Epigenetics in Trained Immunity (f/m/x) 102044

Image Full time
Image Neuherberg near Munich
Image PhD

Your mission

  • Unravelling the signaling function of reactive oxygen and nitrogen species (ROS/NO) in trained immunity
  • Identifying the sources and targets of ROS and NO
  • Characterizing redox-regulated nuclear pathways and investigating redox-regulated epigenetic processes in trained immunity
  • Analyzing the activation of trained immunity in remotely located cells/tissues/organs
  • Developing a controlled activation of trained immunity

Your qualifications

  • Master degree in Biochemistry, Biology, Molecular Biotechnology or equivalent fields
  • Basic experience in at least two of the following areas: Redox-biochemistry, epigenetics, molecular biology, protein biochemistry, structural biology
  • Experience in chromatin analysis, e.g. ATAC-seq, ChIP-seq, WGBS, histone modifications
  • Strong motivation, resilience, scientific curiosity, and commitment to scientific excellence

What we offer you

scientific training at HELENA Graduate School
work-life balance
flexible working hours & time off in lieu
30 days annual leave
on-site health management service
Image career consultation
Image mobile work
Image on-site nursery
Image company pension scheme
Image discounted public transport ticket

Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

This position also provides the opportunity for you to build specialist knowledge and collect significant professional experience, both of which will help advance your scientific career.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of granting an allowance if the necessary conditions are fulfilled. The position is (initially) limited to three years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

If you have further questions, simply contact Dr. Christian Lindermayr, 089 3187-2285, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Lung Health and Immunity
Ingolstädter Landstraße 1 

85764 Oberschleißheim

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