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Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

News on the Corona pandemic
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We continue to recruit and are looking exactly for you. To this end, we have adapted our recruitment process to ensure the greatest possible health protection for both our applicants and our employees. After successfully reviewing your application documents, we will invite you to a friendly video call or telephone interview, no special devices needed. Here we simulate a face-to-face interview situation in order to get to know you better. Fight with us against the spread of environmentally related diseases and apply now.

At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important contribution for a healthier society.

Understanding the epigenetics layout of the early embryonic cells is of paramount importance in order to be able to manipulate cell fate. In particular, how the early gene expression programmes are laid down, and the role of genome organisation and heterochromatin in this process is still largely unknown. Fertilisation of an oocyte by the sperm results in the generation of a totipotent embryo, which has the inherent ability to form a new organism. This is followed by epigenetic reprogramming of both parental genomes.

Our recent work has proposed that heterochromatin formation and nuclear organisation are key features of these early embryonic cells. Further understanding on how the genome unfolds and the role that heterochromatin plays, as well as impact from the nuclear envelope, which protects the chromatin from e.g. mechanical stress, will therefore help us to deepen into the mechanisms that regulate cellular plasticity. Cracking open the nucleus to unlock the cell’s true potential.

Our mission is to understand how cells remember their function in our body, how we can erase such memory, and how we can predict fates using artificial intelligence, in order to manipulate them to perform new functions. We do this by understanding how cells package their genome, how they protect their chromosomes and how they acquire fitness.

We are looking for a highly motivated

Postdoc - Investigation of chromatin reprogramming & genome folding in totipotent cells (f/m/d) 100464

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Your mission

    The successful candidate will develop new approaches to map genome architecture and heterochromatin formation in totipotent cells in vivo and in totipotent-like cells in vitro. The approaches used involve manipulation of mouse early embryos, imaging, NGS, as well as perturbation of the nuclear compartments using biophysical and molecular tools.

    In addition, interdisciplinary approaches and active communication with team members are essential for the project. Working language is English. We offer a well-equipped, international and scientifically stimulating environment for postdoctoral training.

  • Functional analysis of the chromatin modifications in vitro and in vivo (in ES cells and mouse embryos)
  • Drug Screening in a Cellular System -
  • Set up a new model to examine the plasticity of the cell
  • Epigenetic targeting -Scientific analysis of the results
  • Selection and implementation of suitable experimental methods

Your qualifications

  • Ph.D in molecular biology or alike discipline.   
  • Previous experience in molecular biology and epigenetics, specifically in histone variants and their role in chromatin function is required.
  • Experience working in mammalian cell culture systems, including handling and of mouse embryonic stem cells is a pre-requisite.
  • Previous experience in imaging chromatin in ES cells or a suitable cell culture model is also required.
  • Full command of English, written and spoken.
  • Your application should include a CV, a motivation letter with a short research statement, and contact details of two referees.

What we offer you

continuous education & training
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work life balance
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flexible working hours & time off in lieu
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30 days annual leave
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onsite health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to 2 years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.

Interested?
If you have further questions, simply contact Thomas Gerling, +49 89 3187-43691, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Epigenetics and Stem Cells
Marchioninistrasse 25

81377 Munich

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