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Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

Are you passionate about science, full of ideas and innovative potential that drive change, and enjoy working in an international, fast-paced environment? Are you motivated by the societal impact of research and seek an opportunity to play an instrumental part in understanding the underlying molecular pathogenic mechanisms of disease? Then the Institute of Lung Health and Immunity (LHI)/ Comprehensive Pneumology Center (CPC) at Helmholtz Munich, Germany, is the ideal environment for you!

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease and its progression is orchestrated by tissue macrophages. Their functions are regulated by two opposing lipid pathways that initiate inflammation or induce its resolution. Macrophages of COPD patients demonstrate disrupted lipid signaling, resulting in uncontrolled responses and irreversible lung damage. The PhD project will investigate the effects of impaired macrophage lipid signaling in severe-stage COPD patients.

PhD candidate - Research Project Metabolic regulation of macrophage responses in chronic obstructive pulmonary disease (f/m/x) 101779

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Your mission

  • Plan and coordinate sample collection and experimental design with clinical partners
  • Generate and analyze single-cell transcriptomics data from COPD lung biofluids
  • Measure lipid metabolites in lung biofluids with metabolomics
  • Critically assess the effects of lipid signaling on macrophage responses in COPD with ex vivo functional assays
  • Write reports and present work in national and international scientific meetings

Your qualifications

  • Master's degree (merit/distinction) in immunology, biomedical sciences or similar
  • Enthusiasm and willingness to work in an interdisciplinary group consisting of basic scientists, clinicians and bioinformaticians
  • Proficiency in written and spoken English
  • Excellent interpersonal skills and team work
  • Ability to work independently and exhibition of good time management skills

Desired qualifications

  • Additional wet lab experience outside the degree (e.g. internship/research assistant)
  • Prior experience in programming (R/Python)
  • Previous application of single-cell genomics technologies, flow cytometry, human cell culture

What we offer you

scientific training at HELENA Graduate School
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work-life balance
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flexible working hours & time off in lieu
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30 days annual leave
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on-site health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

This position also provides the opportunity for you to build specialist knowledge and collect significant professional experience, both of which will help advance your scientific career.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of granting an allowance if the necessary conditions are fulfilled. The position is (initially) limited to three years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

Interested?
If you have further questions, simply contact Theodoros Kapellos, theodoros.kapellos@helmholtz-muenchen.de, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Lung Health and Immunity
Comprehensive Pneumology Center (CPC)

Max-Lebsche-Platz 31
81377 Munich

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