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Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

The research focus of the Institute of Diabetes Research lays in understanding the pathogenesis of type 1 diabetes, in identifying mechanisms and predictive markers of the disease, and the translation of findings into clinical trials to prevent type 1 diabetes in humans. The Institute is particularly interested in deciphering the molecular mechanisms of islet autoreactivity, and the interaction of environment, genes, and the immune response. The ultimate goal is to develop therapies for the prevention and cure of islet autoimmunity and diabetes.

The type 1 diabetes pathology group headed by Dr. Teresa Rodriguez-Calvo is looking for a highly motivated postdoctoral fellow to join a collaborative group studying the potential dysregulation of the symbiotic relationship between the host immune system and the microbiome, and how this relates to lymphocytes infiltrating the pancreas and the development of type 1 diabetes. The project will use samples provided by the Network for Pancreatic Organ Donors with Diabetes (nPOD), which collects tissue samples from healthy and diabetic organ donors and distributes them to researchers around the world in order to answer basic questions regarding the pathogenesis of type 1 diabetes.

 Postdoctoral position in type 1 diabetes (f/m/d)

Image full time
Image Munich
Image Ph.D., MD/Ph.D

We are looking for a highly motivated individual to work independently and help us to study whether the gut associated lymphoid tissue is abnormal in people with type 1 diabetes, and whether the immune cell repertoire and T cell specificities present in the gut are similar to those found in the pancreas.

The selected candidate will have access to state-of-the-art microscopy techniques, which will allow us to identify different cell populations and quantify their relative abundance as well as their localization in the tissue. The project will utilize advance image analysis, combining machine-learning algorithms with automated software analysis.

The ultimate goal of this exciting postdoctoral project is to understand if there is a disruption of tolerance leading to the dysregulation of the mucosal barrier in the gut and the development of T cells with potential to recognize and kill beta cells.

Your qualification

  • Applicants (Ph.D., MD/Ph.D.) must have a strong background in immunology, microbiology or cell biology.
  • Previous experience in flow cytometry, histology and microscopy along with some background in type 1 diabetes research is highly desirable.
  • A high degree of computer skills is required.
  • Experience in image and data analysis is a plus.

Desired qualifications

  • Good verbal and written communication in English is a must.
  • Applicants should be team players and happy to work in a multi-disciplinary and collaborative environment.
  • International experience is an advantage.

What we offer you

goal-orientated professional development Image
compatibility of private life & work Image
flexible working hours, flexitime, without core times
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30 days vacation per year Image
in-house health management Image
Image a nursery directly at the campus
Image Elder Care & further consultation offers
Image company pension scheme
Image discounted job ticket (MVV and DB)
Image corporate benefits offer

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited to 2 years, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications from talented people regardless of cultural background, nationality, ethnicity, gender and sexual identity, physical abilities, religion and age until 01.12.2020.

Please include your letter of motivation and CV.

Curious?
If you have further questions, simply contact:

Dr. Teresa Rodriguez-Calvo
teresa.rodriguez@helmholtz-muenchen.de.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Diabetes Research  
Heidemannstraße 1

80939 Munich

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