Helmholtz Zentrum München is a research center with the mission to discover personalized medical solutions for the prevention and therapy of environmentally triggered diseases and promote a healthier society in a rapidly changing world.

The Institute of Structural Biology at the Helmholtz Zentrum München focuses on integrative structural biology and structure-based drug discovery, combining structural biology, NMR (nuclear magnetic resonance), crystallography, cryo-EM, computational approaches, and chemical synthesis to develop and apply novel approaches beyond current state-of-the-art for the discovery of new targets and therapeutic small molecules. Therapeutic targets address a range of topics, ranging from diabetescancer, lung disease to targets in parasitic diseases and antibiotic resistance.

Postdoctoral scientist in NMR-based integrative structural biology and drug discovery (f/m/x) 101023

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A postdoc position is available in Biomolecular NMR to implement and develop solution NMR methods, including paramagnetic NMR approaches, for structure-based drug discovery, screening and structural analysis of protein and RNA-ligand complexes.
Our research projects aim at understanding the structure and dynamics of protein and RNA interactions in physiological and disease-linked cellular processes, involved in human disease. The structural data provide a basis for the rational design and development of small molecule inhibitors and novel bioactive compounds towards the development of novel therapeutic approaches.

You will work in an interdisciplinary team that combines state-of-the-art techniques in early stage drug discovery, including NMR fragment-screening and integrative structural biology (combining NMR, X-ray crystallography and cryo-EM with access to state-of-the-art infrastructures), computational methods, including machine-learning/AI, and biophysical characterization to study innovative drug targets of pharmaceutical relevance. Projects integrate close interactions with structural biologists, medicinal chemists and validation with functional and cell-based assays.

Your responsibilities

  • Recombinant production and purification of proteins and RNA
  • NMR-based fragment screening
  • Structural analysis focusing on innovative NMR methods, in combination with crystallography and cryo-EM
  • Computational modelling and structure-based drug design
  • Scientific training and technical mentoring in NMR methods

Your qualifications

  • Doctoral degree in Chemistry, Biochemistry or Physics
  • Excellent training and experience in NMR methods development
  • Experience with paramagnetic NMR methods and fragment screening is advantageous
  • Structure analysis and modelling expertise
  • Familiar with recombinant production and purification of proteins
  • Knowledge of basic biochemical and biophysicamethods to study proteins and RNAs
  • Excellenteam spirit, presentation and communication skills

What we offer you

work-life balance
flexible working hours & working-time models
continuous education and training
30 days annual leave
on-site health management service
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Munich, with its numerous lakes and its vicinity to the Alps, is considered to be one of the cities with the best quality of life worldwide. With its first-class universities and world-leading research institutions it offers an intellectually stimulating environment.

Remuneration and social benefits are based on the collective wage agreement for public-sector employees at federal level (TV EntgO Bund). The position is (initially) limited until 30.09.2023, but under certain circumstances an extension can be arranged.

To promote diversity, we welcome applications until October 31st, 2021 from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
Applicant guidance on the Corona pandemic

If you have further questions, simply contact Prof. Michael Sattler,, who will be happy to be of assistance.
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Structural Biology
Ingolstädter Landstraße 1

85764 Oberschleißheim

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