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Our mission as research center: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world.

As a partner site of the German Center for Lung Research (DZL), an association of the leading university and non-university institutions dedicated to lung research in Germany, the Comprehensive Pneumology Center (CPC) at Helmholtz Munich is dedicated to translational research to combat widespread lung diseases.

We invite applications for

Principal Investigator in Lung Organoids (f/m/x) with Tenure option 101798

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We offer

A Principal Investigator position with Tenure option as head of a DZL Early Career Investigator Group

You and your group will be embedded in the vibrant and thriving local community of the Institute of Lung Health and Immunity (LHI) at the Environmental Health Center Helmholtz Munich, the "Comprehensive Pneumology Center" (CPC) and in the various "Disease Areas" of the German Center for Lung Research (DZL). Within this DZL Early Career Investigator group, you will establish an independent and innovative research program.

At the LHI institute, we are interested in understanding how environmental insults affect human lung health and regeneration, with the aim to develop novel therapeutic strategies against age-associated CLDs, such as COPD. To this end, we focus on the identification of cell-type specific aging programs in the human aged and COPD lung and their effects on lung regeneration to discover environmental insults that contribute to these programs. Moreover, we are interested in deciphering the mechanisms contributing to environment-induced inflamm(aging) in the lung to identify novel pro-regenerative targets as well as potential biomarkers to pave the way towards pro-regenerative “rejuvenating” therapies for age-related chronic inflammatory diseases.

We envision the DZL junior research group to address these focus topics by applying human lung organoids, ex vivo culture models that can be used for mechanistic studies of human lung regeneration, identifying the effect of environmental insults in reprogramming of stem cells as well as the contribution of stem cells to chronic inflammation. Novel insights generated by the DZL Young Investigator Group should be transferable to other diseases that are characterized by chronic inflammation and impaired regeneration to accelerate the development of pro-regenerative therapies across organs.

Your profile

We encourage innovative and enthusiastic scientists to put forward their original scientific proposal with a clear pathway to establishing themselves as drivers in the field. An outstanding track-record, a collaborative and entrepreneurial mindset, good communication skills, and first leadership experience puts you in an ideal position to benefit from and nurture the research at our institute. International and/or industry experience are considered an asset. Potential research areas include, but are not limited to: stem cell reprogramming, epithelial - microenvironment interaction, drug HT screens, inflammaging.

Please submit your cover letter, CV, list of publications (please highlight up to 3 with a brief explanation of their impact), your current and future research plan (3 pages max.) and contact details of three referees as a single PDF via our online submission system until 20.12.2022. The virtual selection symposium including individual interviews will take place in January/February 2023.

To promote diversity, we welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion and age. Qualified applicants with physical disabilities will be given preference.
If you have obtained a university degree abroad, we require further documents from you regarding the recognition of the degree. Please request the recognition as early as possible.

Curious? Questions?

Please get in touch via hauptkorn@helmholtz-muenchen.de
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Institute of Lung Health and Immunity
Comprehensive Pneumology Center
Max-Lebsche-Platz 31

81377 München

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